Developmental regulation of ENaC subunit mRNA levels in rat kidney

To assess the role of distal nephron apical Na channel (ENaC) gene expression in Na wasting by the immature kidney, ENaC alpha-, beta-, and gamma-subunit mRNA levels were examined in the rat by RT-PCR. In microdissected nephron segments, all three ENaC subunit mRNAs were detected in the distal convo...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 1998-06, Vol.43 (6), p.C1661-C1666
Hauptverfasser:	VEHASKARI, V. M, HEMPE, J. M, MANNING, J, AVILES, D. H, CARMICHAEL, M. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cell membranes. Ionic channels. Membrane pores Cell structures and functions Cellular biology Emergency and intensive care: neonates and children. Prematurity. Sudden death Fundamental and applied biological sciences. Psychology Genes Intensive care medicine Kidneys Medical sciences Molecular and cellular biology Ribonucleic acid RNA Vertebrates: urinary system
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Beschreibung
Zusammenfassung:	To assess the role of distal nephron apical Na channel (ENaC) gene expression in Na wasting by the immature kidney, ENaC alpha-, beta-, and gamma-subunit mRNA levels were examined in the rat by RT-PCR. In microdissected nephron segments, all three ENaC subunit mRNAs were detected in the distal convoluted tubule, connecting tubule, cortical collecting duct, and outer medullary collecting duct. The inner medullary collecting duct and all other nephron segments were consistently negative.
ISSN:	0363-6143 1522-1563