Effect of chronic hypoxia on K+ channels : regulation in human pulmonary vascular smooth muscle cells
The effects of chronic hypoxia on the major outward K+ currents in early cultured human main pulmonary arterial smooth muscle cells were examined. The mechanism by which hypoxia modulates NO-induced KCa activation is by decreasing the NO/cGMP-mediated phosphorylation of the channel.
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| Veröffentlicht in: | American Journal of Physiology: Cell Physiology 1997-04, Vol.41 (4), p.C1271-C1278 |
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| container_end_page | C1278 |
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| container_issue | 4 |
| container_start_page | C1271 |
| container_title | American Journal of Physiology: Cell Physiology |
| container_volume | 41 |
| creator | PENG, W HOIDAL, J. R KARWANDE, S. V FARRUKH, I. S |
| description | The effects of chronic hypoxia on the major outward K+ currents in early cultured human main pulmonary arterial smooth muscle cells were examined. The mechanism by which hypoxia modulates NO-induced KCa activation is by decreasing the NO/cGMP-mediated phosphorylation of the channel. |
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S</creatorcontrib><title>Effect of chronic hypoxia on K+ channels : regulation in human pulmonary vascular smooth muscle cells</title><title>American Journal of Physiology: Cell Physiology</title><description>The effects of chronic hypoxia on the major outward K+ currents in early cultured human main pulmonary arterial smooth muscle cells were examined. The mechanism by which hypoxia modulates NO-induced KCa activation is by decreasing the NO/cGMP-mediated phosphorylation of the channel.</description><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Blood vessels</subject><subject>Cell membranes. Ionic channels. Membrane pores</subject><subject>Cell structures and functions</subject><subject>Cellular biology</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Hypertension</topic><topic>Molecular and cellular biology</topic><topic>Muscular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PENG, W</creatorcontrib><creatorcontrib>HOIDAL, J. R</creatorcontrib><creatorcontrib>KARWANDE, S. V</creatorcontrib><creatorcontrib>FARRUKH, I. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><jtitle>American Journal of Physiology: Cell Physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PENG, W</au><au>HOIDAL, J. R</au><au>KARWANDE, S. V</au><au>FARRUKH, I. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of chronic hypoxia on K+ channels : regulation in human pulmonary vascular smooth muscle cells</atitle><jtitle>American Journal of Physiology: Cell Physiology</jtitle><date>1997-04-01</date><risdate>1997</risdate><volume>41</volume><issue>4</issue><spage>C1271</spage><epage>C1278</epage><pages>C1271-C1278</pages><issn>0363-6143</issn><eissn>1522-1563</eissn><coden>AJPCDD</coden><abstract>The effects of chronic hypoxia on the major outward K+ currents in early cultured human main pulmonary arterial smooth muscle cells were examined. The mechanism by which hypoxia modulates NO-induced KCa activation is by decreasing the NO/cGMP-mediated phosphorylation of the channel.</abstract><cop>Bethesda, MD</cop><pub>American Physiological Society</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6143 |
| ispartof | American Journal of Physiology: Cell Physiology, 1997-04, Vol.41 (4), p.C1271-C1278 |
| issn | 0363-6143 1522-1563 |
| language | eng |
| recordid | cdi_proquest_journals_230322511 |
| source | American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Biochemistry Biological and medical sciences Blood vessels Cell membranes. Ionic channels. Membrane pores Cell structures and functions Cellular biology Fundamental and applied biological sciences. Psychology Hypertension Molecular and cellular biology Muscular system |
| title | Effect of chronic hypoxia on K+ channels : regulation in human pulmonary vascular smooth muscle cells |
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