Effect of chronic hypoxia on K+ channels : regulation in human pulmonary vascular smooth muscle cells

The effects of chronic hypoxia on the major outward K+ currents in early cultured human main pulmonary arterial smooth muscle cells were examined. The mechanism by which hypoxia modulates NO-induced KCa activation is by decreasing the NO/cGMP-mediated phosphorylation of the channel.

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Bibliographische Detailangaben
Veröffentlicht in:	American Journal of Physiology: Cell Physiology 1997-04, Vol.41 (4), p.C1271-C1278
Hauptverfasser:	PENG, W, HOIDAL, J. R, KARWANDE, S. V, FARRUKH, I. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and medical sciences Blood vessels Cell membranes. Ionic channels. Membrane pores Cell structures and functions Cellular biology Fundamental and applied biological sciences. Psychology Hypertension Molecular and cellular biology Muscular system
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Beschreibung
Zusammenfassung:	The effects of chronic hypoxia on the major outward K+ currents in early cultured human main pulmonary arterial smooth muscle cells were examined. The mechanism by which hypoxia modulates NO-induced KCa activation is by decreasing the NO/cGMP-mediated phosphorylation of the channel.
ISSN:	0363-6143 1522-1563