Nuclear proteins bind a cis-acting element in the smooth muscle α-actin promoter

Transient transfections of wild-type and mutant chicken smooth muscle (SM) alpha-actin promoter/reporter gene constructs into rat aortic smooth muscle cell showed that the positive transcriptional activity of this region was abolished with a two base pair mutation in a conserved sequence motif at ne...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 1995-05, Vol.37 (5), p.C1259-C1266
Hauptverfasser:	MCNAMARA, C. A, THOMPSON, M. M, VERNON, S. M, SHIMIZU, R. T, BLANK, R. S, OWENS, G. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Cellular biology Contractile proteins Fundamental and applied biological sciences. Psychology Genes Holoproteins Molecular and cellular biology Molecular genetics Muscular system Poultry Proteins Transcription. Transcription factor. Splicing. Rna processing
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Transient transfections of wild-type and mutant chicken smooth muscle (SM) alpha-actin promoter/reporter gene constructs into rat aortic smooth muscle cell showed that the positive transcriptional activity of this region was abolished with a two base pair mutation in a conserved sequence motif at negative225 to negative233. Evidence was offered for binding of a nuclear factor to a positive cis-acting element within the SM alpha-actin promoter.
ISSN:	0363-6143 1522-1563