Reciprocal regulation of cardiac Na-K-ATPase and Na/Ca exchanger : hypertension, thyroid hormone, development

A study tested the hypothesis that cardiac Na/Ca exchanger abundance is regulated in reciprocal fashion to Na-K-ATPase abundance in a number of models known to have altered Na-K-ATPase abundance. The reciprocal regulation of the Na/Ca exchanger and of Na-K-ATPase alpha2-expression provides evidence...

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Veröffentlicht in:American Journal of Physiology: Cell Physiology 1995-09, Vol.38 (3), p.C675-C682
Hauptverfasser: MAGYAR, C. E, JIANGNAN WANG, AZUMA, K. K, MCDONOUGH, A. A
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Sprache:eng
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Zusammenfassung:A study tested the hypothesis that cardiac Na/Ca exchanger abundance is regulated in reciprocal fashion to Na-K-ATPase abundance in a number of models known to have altered Na-K-ATPase abundance. The reciprocal regulation of the Na/Ca exchanger and of Na-K-ATPase alpha2-expression provides evidence for a homeostatic mechanism that would oppose the changes in cellular calcium stores driven by the changes in Na-K-ATPase activity.
ISSN:0363-6143
1522-1563