Molecular and kinetic alterations of muscle AMP deaminase during chronic creatine depletion

We examined a possible mechanism to account for the maintenance of peak AMP deamination rate in fast-twitch muscle of rats fed the creatine analog beta-guanidinopropionic acid (beta-GPA), in spite of reduced abundance of the enzyme AMP deaminase (AMPD).

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Bibliographische Detailangaben
Veröffentlicht in:	American Journal of Physiology: Cell Physiology 1998-02, Vol.43 (2), p.C465-C471
Hauptverfasser:	RUSH, J. W. E, TULLSON, P. C, TERJUNG, R. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Anatomy & physiology Biological and medical sciences Enzymes Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Hydrolases Kinetics Muscular system Proteins Rodents
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Beschreibung
Zusammenfassung:	We examined a possible mechanism to account for the maintenance of peak AMP deamination rate in fast-twitch muscle of rats fed the creatine analog beta-guanidinopropionic acid (beta-GPA), in spite of reduced abundance of the enzyme AMP deaminase (AMPD).
ISSN:	0363-6143 1522-1563