Differential signaling and regulation of apical vs. basolateral EGFR in polarized epithelial cells

Differential signaling and regulation of apical vs. basolateral EGFR in polarized epithelial cells

Overexpression of the epidermal growth factor receptors (EGFR) in polarized kidney epithelial cells caused them to appear in high numbers at both the basolateral and apical cell surfaces. We utilized these cells to look for differences in the regulation and signaling of apical vs. basolateral EGFR.

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Veröffentlicht in:American Journal of Physiology: Cell Physiology 1998-12, Vol.44 (6), p.C1419
Hauptverfasser: Kuwada, Scott K, Lund, Kirk A, Li, Xiu Fen, Cliften, Peter
Format: Artikel
Sprache:eng
Schlagworte:
Anatomy & physiology
Cellular biology
Kidneys
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Zusammenfassung:Overexpression of the epidermal growth factor receptors (EGFR) in polarized kidney epithelial cells caused them to appear in high numbers at both the basolateral and apical cell surfaces. We utilized these cells to look for differences in the regulation and signaling of apical vs. basolateral EGFR.
ISSN:0363-6143
1522-1563