Hypertonic upregulation of amino acid transport system A in vascular smooth muscle cells

Hypertonic upregulation of amino acid transport system A in vascular smooth muscle cells

A study determined the effect of prolonged hypertonicity on solute transport in A10 cells, an established cell line derived from rat aortic smooth muscle. Vascular smooth muscle cells, during prolonged hypertonic stress, activate system A and accumulate specific neutral amino acids that may act as o...

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Veröffentlicht in:American Journal of Physiology: Cell Physiology 1994-08, Vol.36 (2), p.C529
Hauptverfasser: Chen, Jie-Guang, Klus, Lynn R, Steenbergen, Dawn K, Kempson, Stephen A
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Cellular biology
Metabolism
Muscular system
Rodents
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Zusammenfassung:A study determined the effect of prolonged hypertonicity on solute transport in A10 cells, an established cell line derived from rat aortic smooth muscle. Vascular smooth muscle cells, during prolonged hypertonic stress, activate system A and accumulate specific neutral amino acids that may act as organic osmolytes to help maintain normal cell volume.
ISSN:0363-6143
1522-1563