Enantioselective bromination of axially chiral cyanoarenes in the presence of bifunctional organocatalysts

Enantioselective bromination of axially chiral cyanoarenes in the presence of bifunctional organocatalysts

Enantioselective bromination of axially chiral cyanoarenes bearing high intrinsic rotational barriers via dynamic kinetic resolution using bifunctional organocatalysts is reported. Sequential addition of a brominating reagent in several portions at an optimized temperature was effective in accomplis...

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Veröffentlicht in:RSC advances 2019, Vol.9 (54), p.31654-31658
Hauptverfasser: Wada, Yuuki, Matsumoto, Akira, Asano, Keisuke, Matsubara, Seijiro
Format: Artikel
Sprache:eng
Schlagworte:
Bromination
Chemistry
Crystallography
Enantiomers
NMR
Nuclear magnetic resonance
Reagents
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Zusammenfassung:Enantioselective bromination of axially chiral cyanoarenes bearing high intrinsic rotational barriers via dynamic kinetic resolution using bifunctional organocatalysts is reported. Sequential addition of a brominating reagent in several portions at an optimized temperature was effective in accomplishing high enantioselectivities. Enantioselective bromination of axially chiral cyanoarenes bearing high intrinsic rotational barriers via dynamic kinetic resolution using bifunctional organocatalysts is reported.
ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra05532k