Rat proximal tubule cell line transformed with origin-defective SV40 DNA : autocrine ANG II feedback

The renal proximal tubule (PT) is a major site for a complete tissue renin-angiotensin system (RAS) and produces endogenous angiotensin II (ANG II). The present studies demonstrate autocrine RAS feedback in a line of origin-defective SV40 plasmid transformed immortalized rat PT cells (IRPTC) designa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Renal physiology 1999-02, Vol.45 (2), p.F218-F227
Hauptverfasser:	INGELFINGER, J. R, JUNG, F, DIAMANT, D, HAVERAN, L, LEE, E, BREM, A, TANG, S.-S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell physiology Cells Fundamental and applied biological sciences. Psychology Hormonal regulation Kidneys Laboratory animals Molecular and cellular biology Rodents
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The renal proximal tubule (PT) is a major site for a complete tissue renin-angiotensin system (RAS) and produces endogenous angiotensin II (ANG II). The present studies demonstrate autocrine RAS feedback in a line of origin-defective SV40 plasmid transformed immortalized rat PT cells (IRPTC) designated as line 93-p-2-1, which are highly differentiated and express all RAS components.
ISSN:	1931-857X 1522-1466