Dual role of the TRPV4 channel as a sensor of flow and osmolality in renal epithelial cells

Gain/loss of function studies were utilized to assess the potential role of the endogenous vanilloid receptor TRPV4 as a sensor of flow and osmolality in M-1 collecting duct cells (CCD). TRPV4 mRNA and protein were detectable in M-1 cells and stably transfected HEK-293 cells, where the protein occur...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2007-11, Vol.293 (5), p.F1699-F1713
Hauptverfasser:	Wu, Ling, Gao, Xiaochong, Brown, Rachel C, Heller, Stefan, O'Neil, Roger G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Calcium - metabolism Cell Line Cell Membrane - metabolism Cells Culture Media - pharmacology Epithelial Cells - metabolism Fluorescent Antibody Technique Gene expression Glycosylation Humans Hypotonic Solutions - pharmacology Kidney Cortex Kidney Tubules, Collecting - cytology Kidney Tubules, Collecting - metabolism Kidneys Mechanoreceptors - physiology Mice Mice, Inbred C57BL Osmolar Concentration Phorbol Esters - pharmacology Proteins RNA, Messenger - antagonists & inhibitors RNA, Messenger - metabolism RNA, Small Interfering - pharmacology Rodents Shear stress Stress, Mechanical Studies Tissue Distribution Transfection TRPV Cation Channels - antagonists & inhibitors TRPV Cation Channels - genetics TRPV Cation Channels - physiology
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