Chlorpropamide upregulates antidiuretic hormone receptors and unmasks constitutive receptor signaling

Chlorpropamide upregulates antidiuretic hormone receptors and unmasks constitutive receptor signaling

The mechanism by which chlorpropamide (CP) treatment promotes antidiuresis is unknown. CP competitively inhibited antidiuretic hormone (ADH) binding and adenylyl cyclase (AC) stimulation (inhibition constants Ki and Ki' of 2.8 mM and 250 muM, respectively) in the LLC-PK1 cell line.

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Veröffentlicht in:American journal of physiology. Renal physiology 2000-05, Vol.47 (5), p.F799-F808
Hauptverfasser: DURR, J. A, HENSEN, J, EHNIS, T, BLANKENSHIP, M. S, KLEIN, F. C
Format: Artikel
Sprache:eng
Schlagworte:
Anatomy & physiology
Biological and medical sciences
Diabetes
Hormones
Kidneys
Medical sciences
Pharmacology. Drug treatments
Urinary system
Urine
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Zusammenfassung:The mechanism by which chlorpropamide (CP) treatment promotes antidiuresis is unknown. CP competitively inhibited antidiuretic hormone (ADH) binding and adenylyl cyclase (AC) stimulation (inhibition constants Ki and Ki' of 2.8 mM and 250 muM, respectively) in the LLC-PK1 cell line.
ISSN:1931-857X
1522-1466