In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition

The aim of this study was to test the hypothesis that in vivo administration of parathyroid hormone (PTH) provokes diuresis/natriuresis through redistribution of proximal tubule apical sodium cotransporters (NHE3 and NaPi2) to internal stores and inhibition of basolateral Na-K-ATPase activity and to...

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Veröffentlicht in:	American journal of physiology. Renal physiology 1999-05, Vol.45 (5), p.F711-F719
Hauptverfasser:	YIBIN ZHANG, NORIAN, J. M, MAGYAR, C. E, HOLSTEIN-RATHLOU, N.-H, MIRCHEFF, A. K, MCDONOUGH, A. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy & physiology Biological and medical sciences Fundamental and applied biological sciences. Psychology Hormones Kidneys Vertebrates: urinary system
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Beschreibung
Zusammenfassung:	The aim of this study was to test the hypothesis that in vivo administration of parathyroid hormone (PTH) provokes diuresis/natriuresis through redistribution of proximal tubule apical sodium cotransporters (NHE3 and NaPi2) to internal stores and inhibition of basolateral Na-K-ATPase activity and to determine whether the same cellular signals drive the changes in apical and basolateral transporters.
ISSN:	1931-857X 1522-1466