cAMP modulates transepithelial resistance response of LLC-PK1 renal epithelia to tumor necrosis factor

cAMP modulates transepithelial resistance response of LLC-PK1 renal epithelia to tumor necrosis factor

The nature and contribution of the respective signal transduction pathways to tumor necrosis factor-alpha (TNF)-induced regulation of transepithelial resistance (R1) were assessed. The results support a role for 3',5'-cyclic monophosphate and its dependent protein kinase as negative modula...

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Veröffentlicht in:American journal of physiology. Renal physiology 1995-02, Vol.37 (2), p.F315
Hauptverfasser: Marano, Colleen W, Laughlin, Kathleen V, Russo, Linda M, Short, Thomas H, Mullin, James M
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Kidneys
Proteins
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Zusammenfassung:The nature and contribution of the respective signal transduction pathways to tumor necrosis factor-alpha (TNF)-induced regulation of transepithelial resistance (R1) were assessed. The results support a role for 3',5'-cyclic monophosphate and its dependent protein kinase as negative modulators within the signal transduction mechanisms underlying the regulation of transepithelial permeability by TNF.
ISSN:1931-857X
1522-1466