Hypertonicity activates MAP kinases and inhibits HCO3- absorption via distinct pathways in thick ascending limb
Mitogen-activated protein (MAP) kinases are activated by osmotic stress in a variety of cells, but their function and regulation in renal tubules is poorly understood. The present study was designed to examine the osmotic regulation of MAP kinases in the medullary thick ascending limb (MTAL) of the...
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| Veröffentlicht in: | American journal of physiology. Renal physiology 1998-10, Vol.44 (4), p.F478-F486 |
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| container_end_page | F486 |
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| container_issue | 4 |
| container_start_page | F478 |
| container_title | American journal of physiology. Renal physiology |
| container_volume | 44 |
| creator | WATTS, B. A DI MARI, J. F DAVIS, R. J GOOD, D. W |
| description | Mitogen-activated protein (MAP) kinases are activated by osmotic stress in a variety of cells, but their function and regulation in renal tubules is poorly understood. The present study was designed to examine the osmotic regulation of MAP kinases in the medullary thick ascending limb (MTAL) of the rat and to determine their possible role in the hyperosmotic inhibition of HCO-3 absorption in this segment. |
| format | Article |
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A ; DI MARI, J. F ; DAVIS, R. J ; GOOD, D. W</creator><creatorcontrib>WATTS, B. A ; DI MARI, J. F ; DAVIS, R. J ; GOOD, D. W</creatorcontrib><description>Mitogen-activated protein (MAP) kinases are activated by osmotic stress in a variety of cells, but their function and regulation in renal tubules is poorly understood. The present study was designed to examine the osmotic regulation of MAP kinases in the medullary thick ascending limb (MTAL) of the rat and to determine their possible role in the hyperosmotic inhibition of HCO-3 absorption in this segment.</description><identifier>ISSN: 1931-857X</identifier><identifier>EISSN: 1522-1466</identifier><language>eng</language><publisher>Bethesda, MD: American Physiological Society</publisher><subject>Biological and medical sciences ; Cell physiology ; Fundamental and applied biological sciences. Psychology ; Molecular and cellular biology ; Proteins ; Signal transduction ; Urology</subject><ispartof>American journal of physiology. 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| fulltext | fulltext |
| identifier | ISSN: 1931-857X |
| ispartof | American journal of physiology. Renal physiology, 1998-10, Vol.44 (4), p.F478-F486 |
| issn | 1931-857X 1522-1466 |
| language | eng |
| recordid | cdi_proquest_journals_230100868 |
| source | American Physiological Society; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Cell physiology Fundamental and applied biological sciences. Psychology Molecular and cellular biology Proteins Signal transduction Urology |
| title | Hypertonicity activates MAP kinases and inhibits HCO3- absorption via distinct pathways in thick ascending limb |
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