Hypertonicity activates MAP kinases and inhibits HCO3- absorption via distinct pathways in thick ascending limb

Hypertonicity activates MAP kinases and inhibits HCO3- absorption via distinct pathways in thick ascending limb

Mitogen-activated protein (MAP) kinases are activated by osmotic stress in a variety of cells, but their function and regulation in renal tubules is poorly understood. The present study was designed to examine the osmotic regulation of MAP kinases in the medullary thick ascending limb (MTAL) of the...

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Veröffentlicht in:American journal of physiology. Renal physiology 1998-10, Vol.44 (4), p.F478-F486
Hauptverfasser: WATTS, B. A, DI MARI, J. F, DAVIS, R. J, GOOD, D. W
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Cell physiology
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Proteins
Signal transduction
Urology
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Zusammenfassung:Mitogen-activated protein (MAP) kinases are activated by osmotic stress in a variety of cells, but their function and regulation in renal tubules is poorly understood. The present study was designed to examine the osmotic regulation of MAP kinases in the medullary thick ascending limb (MTAL) of the rat and to determine their possible role in the hyperosmotic inhibition of HCO-3 absorption in this segment.
ISSN:1931-857X
1522-1466