Dissimilar mechansims of Ca2+ response to bradykinin in different types of juxtamedullary glomerular arterioles

Dissimilar mechansims of Ca2+ response to bradykinin in different types of juxtamedullary glomerular arterioles

Bradykinin (BK)-induced changes in intracellular calcium level ([Ca2+,) were studied on fura 2-loaded afferent (AA) and efferent glomerular arterioles (EA) microdissected from juxtamedullary renal cortex. A distinction was made between thin and muscular EA. In AA and both types of EA, BK increased [...

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Veröffentlicht in:American journal of physiology. Renal physiology 1999-11, Vol.46 (5), p.F697
Hauptverfasser: Praddaude, F, Marchetti, J, Alhenc-Gelas, F, Ader, J L
Format: Artikel
Sprache:eng
Schlagworte:
Anatomy & physiology
Calcium
Enzymes
Kidneys
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Zusammenfassung:Bradykinin (BK)-induced changes in intracellular calcium level ([Ca2+,) were studied on fura 2-loaded afferent (AA) and efferent glomerular arterioles (EA) microdissected from juxtamedullary renal cortex. A distinction was made between thin and muscular EA. In AA and both types of EA, BK increased [Ca2+], through activation of B2 receptors located only on the endothelium.
ISSN:1931-857X
1522-1466