Angiotensinogen and AT1 antisense inhibition of osteopontin translation in rat proximal tubular cells
Antisense oligonucleotide inhibition of angiotensinogen and ANG II type 1 receptor (AT1) mRNA translation in rat proximal tubules (PT) was examined to provide direct evidence for a role of the renin-angiotensin system (RAS) in upregulated osteopontin expression observed following mechanical cell str...
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| Veröffentlicht in: | American journal of physiology. Renal physiology 2000-05, Vol.47 (5), p.F708-F716 |
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| container_end_page | F716 |
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| container_issue | 5 |
| container_start_page | F708 |
| container_title | American journal of physiology. Renal physiology |
| container_volume | 47 |
| creator | RICARDO, S. D FRANZONI, D. F ROESENER, C. D CRISMAN, J. M DIAMOND, J. R |
| description | Antisense oligonucleotide inhibition of angiotensinogen and ANG II type 1 receptor (AT1) mRNA translation in rat proximal tubules (PT) was examined to provide direct evidence for a role of the renin-angiotensin system (RAS) in upregulated osteopontin expression observed following mechanical cell stretch. Male Sprague-Dawley rats underwent unilateral ureteral obstruction (UUO) under Brevital anesthesia. |
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D ; FRANZONI, D. F ; ROESENER, C. D ; CRISMAN, J. M ; DIAMOND, J. R</creator><creatorcontrib>RICARDO, S. D ; FRANZONI, D. F ; ROESENER, C. D ; CRISMAN, J. M ; DIAMOND, J. R</creatorcontrib><description>Antisense oligonucleotide inhibition of angiotensinogen and ANG II type 1 receptor (AT1) mRNA translation in rat proximal tubules (PT) was examined to provide direct evidence for a role of the renin-angiotensin system (RAS) in upregulated osteopontin expression observed following mechanical cell stretch. Male Sprague-Dawley rats underwent unilateral ureteral obstruction (UUO) under Brevital anesthesia.</description><identifier>ISSN: 1931-857X</identifier><identifier>EISSN: 1522-1466</identifier><language>eng</language><publisher>Bethesda, MD: American Physiological Society</publisher><subject>Biological and medical sciences ; Cellular biology ; Enzymes ; Kidneys ; Medical sciences ; Nephrology. Urinary tract diseases ; Proteins ; Ribonucleic acid ; RNA ; Rodents ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland</subject><ispartof>American journal of physiology. Renal physiology, 2000-05, Vol.47 (5), p.F708-F716</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright American Physiological Society May 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1538417$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>RICARDO, S. D</creatorcontrib><creatorcontrib>FRANZONI, D. F</creatorcontrib><creatorcontrib>ROESENER, C. D</creatorcontrib><creatorcontrib>CRISMAN, J. M</creatorcontrib><creatorcontrib>DIAMOND, J. R</creatorcontrib><title>Angiotensinogen and AT1 antisense inhibition of osteopontin translation in rat proximal tubular cells</title><title>American journal of physiology. Renal physiology</title><description>Antisense oligonucleotide inhibition of angiotensinogen and ANG II type 1 receptor (AT1) mRNA translation in rat proximal tubules (PT) was examined to provide direct evidence for a role of the renin-angiotensin system (RAS) in upregulated osteopontin expression observed following mechanical cell stretch. Male Sprague-Dawley rats underwent unilateral ureteral obstruction (UUO) under Brevital anesthesia.</description><subject>Biological and medical sciences</subject><subject>Cellular biology</subject><subject>Enzymes</subject><subject>Kidneys</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Proteins</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Rodents</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><issn>1931-857X</issn><issn>1522-1466</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNotT8tKBDEQHETBdfUfgngdSCavmeOy-IIFD-7B29DJ9qxZYjImGdC_N6iHprq7iurqs2bFZNe1TCh1XvuBs7aX-u2yucr5RCllrGOrBjfh6GLBkF2IRwwEwoFs9qxicbmukbjw7owrLgYSJxJzwTjHygZSEoTs4ZeqY4JC5hS_3Ad4UhazeEjEovf5urmYwGe8-cd18_pwv98-tbuXx-ftZtfOUtFWG-jQIIClplYHRtneDihQQK8lojocuKFaDspYqTRlHIW2laFCyImvm9s_1xric8FcxlNcUqgHx45T2g9M0yq6-xdBtuCn-oJ1eZxTTZ2-RyZ5L5jmP-3TYWQ</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>RICARDO, S. D</creator><creator>FRANZONI, D. F</creator><creator>ROESENER, C. D</creator><creator>CRISMAN, J. 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Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RICARDO, S. D</creatorcontrib><creatorcontrib>FRANZONI, D. F</creatorcontrib><creatorcontrib>ROESENER, C. D</creatorcontrib><creatorcontrib>CRISMAN, J. M</creatorcontrib><creatorcontrib>DIAMOND, J. R</creatorcontrib><collection>Pascal-Francis</collection><jtitle>American journal of physiology. Renal physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RICARDO, S. D</au><au>FRANZONI, D. F</au><au>ROESENER, C. D</au><au>CRISMAN, J. M</au><au>DIAMOND, J. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensinogen and AT1 antisense inhibition of osteopontin translation in rat proximal tubular cells</atitle><jtitle>American journal of physiology. Renal physiology</jtitle><date>2000-05-01</date><risdate>2000</risdate><volume>47</volume><issue>5</issue><spage>F708</spage><epage>F716</epage><pages>F708-F716</pages><issn>1931-857X</issn><eissn>1522-1466</eissn><abstract>Antisense oligonucleotide inhibition of angiotensinogen and ANG II type 1 receptor (AT1) mRNA translation in rat proximal tubules (PT) was examined to provide direct evidence for a role of the renin-angiotensin system (RAS) in upregulated osteopontin expression observed following mechanical cell stretch. Male Sprague-Dawley rats underwent unilateral ureteral obstruction (UUO) under Brevital anesthesia.</abstract><cop>Bethesda, MD</cop><pub>American Physiological Society</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1931-857X |
| ispartof | American journal of physiology. Renal physiology, 2000-05, Vol.47 (5), p.F708-F716 |
| issn | 1931-857X 1522-1466 |
| language | eng |
| recordid | cdi_proquest_journals_230089170 |
| source | American Physiological Society Paid; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Cellular biology Enzymes Kidneys Medical sciences Nephrology. Urinary tract diseases Proteins Ribonucleic acid RNA Rodents Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland |
| title | Angiotensinogen and AT1 antisense inhibition of osteopontin translation in rat proximal tubular cells |
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