Angiotensinogen and AT1 antisense inhibition of osteopontin translation in rat proximal tubular cells

Antisense oligonucleotide inhibition of angiotensinogen and ANG II type 1 receptor (AT1) mRNA translation in rat proximal tubules (PT) was examined to provide direct evidence for a role of the renin-angiotensin system (RAS) in upregulated osteopontin expression observed following mechanical cell str...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Renal physiology 2000-05, Vol.47 (5), p.F708-F716
Hauptverfasser:	RICARDO, S. D, FRANZONI, D. F, ROESENER, C. D, CRISMAN, J. M, DIAMOND, J. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cellular biology Enzymes Kidneys Medical sciences Nephrology. Urinary tract diseases Proteins Ribonucleic acid RNA Rodents Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Antisense oligonucleotide inhibition of angiotensinogen and ANG II type 1 receptor (AT1) mRNA translation in rat proximal tubules (PT) was examined to provide direct evidence for a role of the renin-angiotensin system (RAS) in upregulated osteopontin expression observed following mechanical cell stretch. Male Sprague-Dawley rats underwent unilateral ureteral obstruction (UUO) under Brevital anesthesia.
ISSN:	1931-857X 1522-1466