NHE3 serves as a molecular tool for cAMP-mediated regulation of receptor-mediated endocytosis

Receptor-mediated, clathrin-dependent endocytosis (RME) is important for macromolecular transport and regulation of cell-surface protein expression. Pharmacological studies have shown that the plasma membrane transport protein Na+/H+ exchanger 3, which shuttles between the plasma membrane and the ea...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2002-09, Vol.52 (3), p.F549-F558
Hauptverfasser:	GEKLE, Michael, SERRANO, Oscar K, DRUMM, Karina, MILDENBERGER, Sigrid, FREUDINGER, Ruth, GASSNER, Birgit, JANSEN, Hans Willi, CHRISTENSEN, Erik I
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Hydrogen Kidneys Molecules Sodium Vertebrates: urinary system
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Receptor-mediated, clathrin-dependent endocytosis (RME) is important for macromolecular transport and regulation of cell-surface protein expression. Pharmacological studies have shown that the plasma membrane transport protein Na+/H+ exchanger 3, which shuttles between the plasma membrane and the early endosomal compartment by means of clathrin-mediated endocytosis, contributes to endosomal pH homeostasis and endocytic fusion events.
ISSN:	1931-857X 1522-1466