Male gender increases sensitivity to proteinuria induced by mild NOS inhibition in rats: role of sex hormones

Men are at greater risk for renal injury than women. Verhagen et al studied whether male rats are more sensitive to the hypertensive and proteinuric effects of chronic nitric oxide synthase (NOS) inhibition than female rats, and whether androgens or estrogens are responsible for differences in sensitivity to proteinuria induced by chronic NOS inhibition.