Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase

The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucl...

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Veröffentlicht in:	British journal of cancer 2001-06, Vol.84 (12), p.1677-1680
Hauptverfasser:	Cuq, P, Rouquet, C, Evrard, A, Ciccolini, J, Vian, L, Cano, J-P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - pharmacology Antineoplastic agents Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - pathology Cancer Research Cloning Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Cytotoxicity Drug Resistance Epidemiology Female Fluorouracil - pharmacology Gene therapy Genetic Therapy Humans Medical research Medical sciences Metabolism Metabolites Molecular Medicine Oncology Pharmacology. Drug treatments regular-article Ribonucleotides Transfection Tumor Cells, Cultured Uridine Phosphorylase - biosynthesis Uridine Phosphorylase - genetics Uridine Phosphorylase - metabolism
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Zusammenfassung:	The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucleotide pathway, does not increase the fluoropyrimidine sensitivity of MCF-7 human cancer cells. © 2001 Cancer Research Campaign http://www.bjcancer.com
ISSN:	0007-0920 1532-1827 1532-1827
DOI:	10.1054/bjoc.2001.1833