Drug interactions and pharmacogenetic factors contribute to variation in apixaban concentration in atrial fibrillation patients in routine care

Factor Xa-inhibitor apixaban is an oral anticoagulant prescribed in atrial fibrillation (AF) for stroke prevention. Its pharmacokinetic profile is known to be affected by cytochrome P450 (CYP)3A metabolism, while it is also a substrate of the efflux transporters ATP-binding cassette (ABC)B1 (P-glyco...

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Veröffentlicht in:Journal of thrombosis and thrombolysis 2020-02, Vol.49 (2), p.294-303
Hauptverfasser: Gulilat, Markus, Keller, Denise, Linton, Bradley, Pananos, A. Demetri, Lizotte, Daniel, Dresser, George K., Alfonsi, Jeffrey, Tirona, Rommel G., Kim, Richard B., Schwarz, Ute I.
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Sprache:eng
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