IGFs stimulate zebrafish cell proliferation by activating MAP kinase and PI3-kinase-signaling pathways

IGFs stimulate zebrafish cell proliferation by activating MAP kinase and PI3-kinase-signaling pathways

Insulin-like growth factor (IGF)-I and -II have been cloned from a number of teleost species, but their cellular actions in fish are poorly defined. In this study, we show that both IGF-I and -II stimulated zebrafish embryonic cell proliferation and DNA synthesis in a concentration-dependent manner,...

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Veröffentlicht in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2001-04, Vol.49 (4), p.R1230-R1239
Hauptverfasser: POZIOS, Kasiani C, JUN DING, DEGGER, Brian, UPTON, Zee, CUNMING DUAN
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Cell cycle, cell proliferation
Cell physiology
Cells
Embryos
Fish
Fundamental and applied biological sciences. Psychology
Insulin
Molecular and cellular biology
Peptides
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Zusammenfassung:Insulin-like growth factor (IGF)-I and -II have been cloned from a number of teleost species, but their cellular actions in fish are poorly defined. In this study, we show that both IGF-I and -II stimulated zebrafish embryonic cell proliferation and DNA synthesis in a concentration-dependent manner, whereas insulin had little mitogenic activity.
ISSN:0363-6119
1522-1490