Effects of a unique conjugate of α-lipoic acid and γ-linolenic acid on insulin action in obese Zucker rats

Effects of a unique conjugate of α-lipoic acid and γ-linolenic acid on insulin action in obese Zucker rats

The purpose of this study was to assess the individual and interactive effects of the antioxidant alphax-lipoic acid (LPA) and the n-6 essential fatty acid gamma-linolenic acid (GLA) on insulin action in insulin-resistant obese Zucker rats. LPA, GLA, and a unique conjugate consisting of equimolar pa...

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Veröffentlicht in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2000-02, Vol.47 (2), p.R453-R459
Hauptverfasser: PETH, J. A, KINNICK, T. R, YOUNGBLOOD, E. B, TRITSCHLER, H. J, HENRIKSEN, E. J
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Insulin
Medical sciences
Metabolic diseases
Metabolism
Muscular system
Obesity
Rodents
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Zusammenfassung:The purpose of this study was to assess the individual and interactive effects of the antioxidant alphax-lipoic acid (LPA) and the n-6 essential fatty acid gamma-linolenic acid (GLA) on insulin action in insulin-resistant obese Zucker rats. LPA, GLA, and a unique conjugate consisting of equimolar parts of LPA and GLA (LPA-GLA) were administered for 14 days at 10, 30, or 50 mg-kg body wt-1 - day-1.
ISSN:0363-6119
1522-1490