Role of cytochrome P-450 in endogenous antipyresis

In previous reports, we (15, 18) and others (29) demonstrated data showing that various inhibitors of cytochrome P-450/epoxygenase augment fever in rats and mice, indicating that the enzyme may be involved in endogenous antipyresis. The aim of this study was to further test the hypothesis that the P...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2000-08, Vol.48 (2), p.R455-R460
Hauptverfasser:	KOZAK, W, KLUGER, M. J, KOZAK, A, WACHULEC, M, DOKLADNY, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Enzymes Fever Fundamental and applied biological sciences. Psychology Rodents Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Zusammenfassung:	In previous reports, we (15, 18) and others (29) demonstrated data showing that various inhibitors of cytochrome P-450/epoxygenase augment fever in rats and mice, indicating that the enzyme may be involved in endogenous antipyresis. The aim of this study was to further test the hypothesis that the P-450-dependent epoxygenase pathway of arachidonic acid is part of the homeostatic system to control the height of fever.
ISSN:	0363-6119 1522-1490