IGF-I stimulates protein synthesis but does not inhibit protein breakdown in muscle from septic rats

IGF-I stimulates protein synthesis but does not inhibit protein breakdown in muscle from septic rats

Sepsis is associated with reduced protein synthesis and increased protein degradation in skeletal muscle. We examined the effects of insulin-like growth factor I (IGF-I) on protein synthesis and breakdown in muscles from nonseptic and septic rats.

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Bibliographische Detailangaben
Veröffentlicht in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-02, Vol.43 (2), p.R571-R576
Hauptverfasser: HOBLER, S. C, WILLIAMS, A. B, FISCHER, J. E, HASSELGREN, P.-O
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
General aspects
Hormones
Human infectious diseases. Experimental studies and models
Infectious diseases
Medical sciences
Muscular system
Proteins
Rodents
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Zusammenfassung:Sepsis is associated with reduced protein synthesis and increased protein degradation in skeletal muscle. We examined the effects of insulin-like growth factor I (IGF-I) on protein synthesis and breakdown in muscles from nonseptic and septic rats.
ISSN:0363-6119
1522-1490