Prejunctional M1 facilitory and M2 inhibitory muscarinic receptors mediate rat bladder contractility

Subtype-selective muscarinic antagonists effects on carbachol-induced and electric field-stimulated contractility of rat bladder were compared in vitro. Schild plot analysis of cumulative carbachol dose response curves in the presence of antagonists was consistent with M3-mediated bladder contractio...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-02, Vol.43 (2), p.R517-R523
Hauptverfasser:	BRAVERMAN, A. S, KOHN, I. J, LUTHIN, G. R, RUGGIERI, M. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Fundamental and applied biological sciences. Psychology Molecules Muscular system Pharmacology Rodents Urology Vertebrates: urinary system
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Zusammenfassung:	Subtype-selective muscarinic antagonists effects on carbachol-induced and electric field-stimulated contractility of rat bladder were compared in vitro. Schild plot analysis of cumulative carbachol dose response curves in the presence of antagonists was consistent with M3-mediated bladder contractions.
ISSN:	0363-6119 1522-1490