M2 muscarinic receptor contributes to contraction of the denervated rat urinary bladder

M2 muscarinic receptor contributes to contraction of the denervated rat urinary bladder

In vitro bladder contractions in response to cumulative carbachol doses were measured in the presence of selective muscarinic antagonists from rats that had their major pelvic ganglion bilaterally removed. Denervation induced both hypertrophy and a supersensitivity of the bladders to agonist.

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Bibliographische Detailangaben
Veröffentlicht in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1998-11, Vol.44 (5), p.R1654-R1660
Hauptverfasser: BRAVERMAN, A. S, LUTHIN, G. R, RUGGIERI, M. R
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Muscular system
Pharmacology
Rodents
Urology
Vertebrates: urinary system
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Zusammenfassung:In vitro bladder contractions in response to cumulative carbachol doses were measured in the presence of selective muscarinic antagonists from rats that had their major pelvic ganglion bilaterally removed. Denervation induced both hypertrophy and a supersensitivity of the bladders to agonist.
ISSN:0363-6119
1522-1490