Critical oxygen tension in rat brain : a combined 31P-NMR and EPR oximetry study

The relationship between cerebral interstitial oxygen tension (Pto2) and cellular energetics was investigated in mechanically ventilated, anesthetized rats during progressive acute hypoxia to determine whether there is a "critical" brain Pto2 for maintaining steady-state aerobic metabolism...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2000-07, Vol.48 (1), p.R9-R16
Hauptverfasser:	ROLETT, E. L, AZZAWI, A, KE JIAN LIU, YONGBI, M. N, SWARTZ, H. M, DUNN, J. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry and metabolism Biological and medical sciences Brain Central nervous system Fundamental and applied biological sciences. Psychology Neurology NMR Nuclear magnetic resonance Oxygen Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	The relationship between cerebral interstitial oxygen tension (Pto2) and cellular energetics was investigated in mechanically ventilated, anesthetized rats during progressive acute hypoxia to determine whether there is a "critical" brain Pto2 for maintaining steady-state aerobic metabolism. Cerebral Pto2, measured by electron paramagnetic resonance oximetry, decreased proportionately to inspired oxygen fraction.
ISSN:	0363-6119 1522-1490