Kinetic analysis of muscarinic receptors in human brain and salivary gland in vivo

The hypothesis that the employment of the IQNB enantiomers, together with the analysis of ligand metabolites and pharmacokinetic analyses, could be useful for studies of human muscarinic-cholinergic receptors (mAChRs) was tested. The distribution of mAChRs in brain regions and parotid glands of heal...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1995-06, Vol.37 (6), p.R1491-R1499
Hauptverfasser:	HIRAMATSU, Y, ECKELMAN, W. C, CARRASQUILLO, J. A, MILETICH, R. S, VALDEZ, I. H, KURRASCH, R. H. M, MACYNSKI, A. A, PAIK, C. H, NEUMANN, R. D, BAUM, B. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry and metabolism Biological and medical sciences Brain Central nervous system Endocrine system Fundamental and applied biological sciences. Psychology Kinetics Pharmacology Vertebrates: nervous system and sense organs
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Zusammenfassung:	The hypothesis that the employment of the IQNB enantiomers, together with the analysis of ligand metabolites and pharmacokinetic analyses, could be useful for studies of human muscarinic-cholinergic receptors (mAChRs) was tested. The distribution of mAChRs in brain regions and parotid glands of healthy human volunteers in vivo was examined. RR-IQNB has value when used for studies of human brain mAChRs.
ISSN:	0363-6119 1522-1490