Role of chloride in constriction of descending vasa recta by angiotensin II

We investigated the dependence of ANG II (10(-8) M)-induced constriction of outer medullary descending vasa recta (OMDVR) on membrane potential (psim) and chloride ion. ANG II depolarized OMDVR, as measured by fully loading them with the voltage-sensitive dye bis[1,3-dibutylbarbituric acid-(5)] trim...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2001-06, Vol.49 (6), p.R1878-R1886
Hauptverfasser:	ZHONG ZHANG, HUANG, James M. C, TURNER, Malcolm R, RHINEHART, Kristie L, PALLONE, Thomas L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Biological and medical sciences Brain Circulatory system Fundamental and applied biological sciences. Psychology Kidneys Vertebrates: urinary system
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Zusammenfassung:	We investigated the dependence of ANG II (10(-8) M)-induced constriction of outer medullary descending vasa recta (OMDVR) on membrane potential (psim) and chloride ion. ANG II depolarized OMDVR, as measured by fully loading them with the voltage-sensitive dye bis[1,3-dibutylbarbituric acid-(5)] trimethineoxonol [DiBAC4(3)] or selectively loading their pericytes.
ISSN:	0363-6119 1522-1490