Chronic alcohol consumption increases sensitivity to the anorexic effect of cholecystokinin

The ability of intraperitoneal cholecystokinin COOH-terminal octapeptide to suppress food intake in rats that had consumed a control diet of ethanol in sucrose or sucrose alone for six months was examined. Results are consistent with the hypothesis that ethanol, when taken on a chronic basis, increases the sensitivity to cholecystokinin octapeptides.