Effects of endothelin-1 and homologous trout endothelin on cardiovascular function in rainbow trout

The cardiovascular effects of endothelin (ET)-1 and the recently sequenced homologous trout ET were examined in unanesthetized trout, and vascular capacitance curves were constructed to evaluate the responsiveness of the venous system to ET-1. A bolus dose of 667 pmol/kg ET-1 doubled ventral aortic...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2000-02, Vol.47 (2), p.R460-R468
Hauptverfasser:	HOAGLAND, T. M, WEAVER, L. JR, CONLON, J. M, YUGI WANG, OLSON, K. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Circulatory system Fish Fundamental and applied biological sciences. Psychology Heart Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Peptides Vertebrates: nervous system and sense organs
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Zusammenfassung:	The cardiovascular effects of endothelin (ET)-1 and the recently sequenced homologous trout ET were examined in unanesthetized trout, and vascular capacitance curves were constructed to evaluate the responsiveness of the venous system to ET-1. A bolus dose of 667 pmol/kg ET-1 doubled ventral aortic pressure; produced a triphasic pressor-depressor-pressor response in dorsal aortic pressure (PDA increased central venous pressure, gill resistance, and systemic resistance; and decreased cardiac output, heart rate, and stroke volume.
ISSN:	0363-6119 1522-1490