Renal medullary nitric oxide deficit of Dahl S rats enhances hypertensive actions of angiotensin II

Renal medullary nitric oxide deficit of Dahl S rats enhances hypertensive actions of angiotensin II

Szentivanyi et al examined the hypothesis that the renal medulla of Dahl salt-sensitive (Dahl S) rats has a reduced capacity to generate nitric oxide (NO), which diminishes the ability to buffer against the chronic hypertensive effects of small elevations of circulating ANG II. NO synthase (NOS) act...

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Veröffentlicht in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2002-07, Vol.52 (1), p.R266-R272
Hauptverfasser: SZENTIVANYI, Matyas JR, ZOU, Ai-Ping, MATTSON, David L, SOARES, Paulo, MORENO, Carol, ROMAN, Richard J, COWLEY, Allen W
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Experimental diseases
Hypertension
Kidneys
Medical sciences
Nitric oxide
Rodents
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Zusammenfassung:Szentivanyi et al examined the hypothesis that the renal medulla of Dahl salt-sensitive (Dahl S) rats has a reduced capacity to generate nitric oxide (NO), which diminishes the ability to buffer against the chronic hypertensive effects of small elevations of circulating ANG II. NO synthase (NOS) activity in the outer medulla of Dahl S rats was significantly reduced.
ISSN:0363-6119
1522-1490