Bladder injection of naked hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivo
The goal of these studies was to examine the potential utility of baldder instilled K+ channel gene therapy with hSlo cDNA (i.e., the maxi-K channel) to ameliorate bladder overactivity in a rat model of partial urinary outlet obstruction. Twenty-two female Sprague-Dawley rats were subjected to parti...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2001-11, Vol.50 (5), p.R1699-R1709 |
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| container_end_page | R1709 |
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| container_issue | 5 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
| container_volume | 50 |
| creator | CHRIST, G. J DAY, N. S MELMAN, A DAY, M SANTIZO, C ZHAO, W SCLAFANI, T ZINMAN, J HSIEH, K VENKATESWARLU, K VALCIC, M |
| description | The goal of these studies was to examine the potential utility of baldder instilled K+ channel gene therapy with hSlo cDNA (i.e., the maxi-K channel) to ameliorate bladder overactivity in a rat model of partial urinary outlet obstruction. Twenty-two female Sprague-Dawley rats were subjected to partial urethral (i.e., outlet) obstruction, with 17 sham-operated control rates run in parallel. |
| format | Article |
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J ; DAY, N. S ; MELMAN, A ; DAY, M ; SANTIZO, C ; ZHAO, W ; SCLAFANI, T ; ZINMAN, J ; HSIEH, K ; VENKATESWARLU, K ; VALCIC, M</creator><creatorcontrib>CHRIST, G. J ; DAY, N. S ; MELMAN, A ; DAY, M ; SANTIZO, C ; ZHAO, W ; SCLAFANI, T ; ZINMAN, J ; HSIEH, K ; VENKATESWARLU, K ; VALCIC, M</creatorcontrib><description>The goal of these studies was to examine the potential utility of baldder instilled K+ channel gene therapy with hSlo cDNA (i.e., the maxi-K channel) to ameliorate bladder overactivity in a rat model of partial urinary outlet obstruction. 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| identifier | ISSN: 0363-6119 |
| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 2001-11, Vol.50 (5), p.R1699-R1709 |
| issn | 0363-6119 1522-1490 |
| language | eng |
| recordid | cdi_proquest_journals_229711372 |
| source | American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences Digestive system Injections Medical sciences Muscular system Nephrology. Urinary tract diseases Rodents Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Urine |
| title | Bladder injection of naked hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivo |
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