Bladder injection of naked hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivo

The goal of these studies was to examine the potential utility of baldder instilled K+ channel gene therapy with hSlo cDNA (i.e., the maxi-K channel) to ameliorate bladder overactivity in a rat model of partial urinary outlet obstruction. Twenty-two female Sprague-Dawley rats were subjected to parti...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2001-11, Vol.50 (5), p.R1699-R1709
Hauptverfasser:	CHRIST, G. J, DAY, N. S, MELMAN, A, DAY, M, SANTIZO, C, ZHAO, W, SCLAFANI, T, ZINMAN, J, HSIEH, K, VENKATESWARLU, K, VALCIC, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Digestive system Injections Medical sciences Muscular system Nephrology. Urinary tract diseases Rodents Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Urine
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Zusammenfassung:	The goal of these studies was to examine the potential utility of baldder instilled K+ channel gene therapy with hSlo cDNA (i.e., the maxi-K channel) to ameliorate bladder overactivity in a rat model of partial urinary outlet obstruction. Twenty-two female Sprague-Dawley rats were subjected to partial urethral (i.e., outlet) obstruction, with 17 sham-operated control rates run in parallel.
ISSN:	0363-6119 1522-1490