Diminshed arteriolar responses in nitrate tolerance involve ROS and angiotensin II

Diminshed arteriolar responses in nitrate tolerance involve ROS and angiotensin II

Our purpose was to evaluate hyporesponsivity to nitric oxide (NO)-induced dilation in small arteriols during nitrate tolerance. An Alza osmotic pump was implatned in the left flank of adult rats ( n = 56) for continuous administration of nitroglycerin (140 mug/h) or vehicle (propylene glycol).

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Bibliographische Detailangaben
Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 2002-06, Vol.51 (6), p.H2377
Hauptverfasser: Frame, Mary D, Fox, Randall J, Kim, Dongsoo, Mohan, Amy
Format: Artikel
Sprache:eng
Schlagworte:
Cardiovascular disease
Circulatory system
Drug therapy
Heart failure
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Zusammenfassung:Our purpose was to evaluate hyporesponsivity to nitric oxide (NO)-induced dilation in small arteriols during nitrate tolerance. An Alza osmotic pump was implatned in the left flank of adult rats ( n = 56) for continuous administration of nitroglycerin (140 mug/h) or vehicle (propylene glycol).
ISSN:0363-6135
1522-1539