Differential role of ionotropic glutamatergic mechanisms in responses to NTS P2x and A2a receptor stimulation

Activation of ATP P2z receptors in the subpostremal nucleus tractus solitarii (NTS) via microinjection of alpha,beta-methylene ATP (alpha,beta-MeATP) elicits fast initial depressor and sympathoinhibitory responses that are followed by slow, long-lasting inhibitory effects. Activation of NTS adenosin...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2000-06, Vol.47 (6), p.H2057-H2068
Hauptverfasser:	SCISLO, T. J, O'LEARY, D. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Fundamental and applied biological sciences. Psychology Kidneys Nervous system Vertebrates: nervous system and sense organs
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Zusammenfassung:	Activation of ATP P2z receptors in the subpostremal nucleus tractus solitarii (NTS) via microinjection of alpha,beta-methylene ATP (alpha,beta-MeATP) elicits fast initial depressor and sympathoinhibitory responses that are followed by slow, long-lasting inhibitory effects. Activation of NTS adenosine A2a receptors via microinjection of CGS-21680 elicits slow, long-lasting decreases in arterial pressure and renal sympathetic nerve activity (RSNA) and an increase in preganglionic adrenal sympathetic nerve activity (pre-ASNA).
ISSN:	0363-6135 1522-1539