Short-term cardiac memory and mother rotor fibrillation
University of California, Los Angeles (UCLA) Cardiovascular Research Laboratory, Departments of Medicine (Cardiology), Physiology, and Physiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California Submitted 2 September 2005 ; accepted in final form 18 June 2006 Short-term...
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container_title | American journal of physiology. Heart and circulatory physiology |
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creator | Baher, Ali Qu, Zhilin Hayatdavoudi, Ashkan Lamp, Scott T Yang, Ming-Jim Xie, Fagen Turner, Stephen Garfinkel, Alan Weiss, James N |
description | University of California, Los Angeles (UCLA) Cardiovascular Research Laboratory, Departments of Medicine (Cardiology), Physiology, and Physiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California
Submitted 2 September 2005
; accepted in final form 18 June 2006
Short-term cardiac memory refers to the effects of pacing history on action potential duration (APD). Although the ionic mechanisms for short-term memory occurring over many heartbeats (also called APD accommodation) are poorly understood, they may have important effects on reentry and fibrillation. To explore this issue, we incorporated a generic memory current into the Phase I Luo and Rudy action potential model, which lacks short-term memory. The properties of this current were matched to simulate quantitatively human ventricular monophasic action potential accommodation. We show that, theoretically, short-term memory can resolve the paradox of how mother rotor fibrillation is initiated in heterogeneous tissue by physiological pacing. In simulated heterogeneous two-dimensional tissue and three-dimensional ventricles containing an inward rectifier K + current gradient, short-term memory could spontaneously convert multiple wavelet fibrillation to mother rotor fibrillation or to a mixture of both fibrillation types. This was due to progressive acceleration and stabilization of rotors as accumulation of memory shortened APD and flattened APD restitution slope nonuniformly throughout the tissue.
ventricular fibrillation; mathematical modeling; electrical restitution; action potential accommodation
Address for reprint requests and other correspondence: J. N. Weiss, David Geffen School of Medicine at UCLA, Division of Cardiology, 47-123 CHS, 10833 LeConte Ave., Los Angeles, CA 90095-1679 (e-mail: jweiss{at}mednet.ucla.edu ) |
doi_str_mv | 10.1152/ajpheart.00944.2005 |
format | Article |
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Submitted 2 September 2005
; accepted in final form 18 June 2006
Short-term cardiac memory refers to the effects of pacing history on action potential duration (APD). Although the ionic mechanisms for short-term memory occurring over many heartbeats (also called APD accommodation) are poorly understood, they may have important effects on reentry and fibrillation. To explore this issue, we incorporated a generic memory current into the Phase I Luo and Rudy action potential model, which lacks short-term memory. The properties of this current were matched to simulate quantitatively human ventricular monophasic action potential accommodation. We show that, theoretically, short-term memory can resolve the paradox of how mother rotor fibrillation is initiated in heterogeneous tissue by physiological pacing. In simulated heterogeneous two-dimensional tissue and three-dimensional ventricles containing an inward rectifier K + current gradient, short-term memory could spontaneously convert multiple wavelet fibrillation to mother rotor fibrillation or to a mixture of both fibrillation types. This was due to progressive acceleration and stabilization of rotors as accumulation of memory shortened APD and flattened APD restitution slope nonuniformly throughout the tissue.
ventricular fibrillation; mathematical modeling; electrical restitution; action potential accommodation
Address for reprint requests and other correspondence: J. N. Weiss, David Geffen School of Medicine at UCLA, Division of Cardiology, 47-123 CHS, 10833 LeConte Ave., Los Angeles, CA 90095-1679 (e-mail: jweiss{at}mednet.ucla.edu )</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.00944.2005</identifier><identifier>PMID: 16891403</identifier><identifier>CODEN: AJPPDI</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Action Potentials ; Adaptation, Physiological ; Animals ; Cardiac arrhythmia ; Cardiology ; Cardiovascular system ; Computer Simulation ; Heart ; Heart Conduction System - physiopathology ; Models, Cardiovascular ; Rabbits ; Ventricular Fibrillation - physiopathology</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2007-01, Vol.292 (1), p.H180-H189</ispartof><rights>Copyright American Physiological Society Jan 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-d83347cd14dc95c4f089fb8f2020aa4ce23a435c8503f79e8dd47f468d6c091d3</citedby><cites>FETCH-LOGICAL-c420t-d83347cd14dc95c4f089fb8f2020aa4ce23a435c8503f79e8dd47f468d6c091d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16891403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baher, Ali</creatorcontrib><creatorcontrib>Qu, Zhilin</creatorcontrib><creatorcontrib>Hayatdavoudi, Ashkan</creatorcontrib><creatorcontrib>Lamp, Scott T</creatorcontrib><creatorcontrib>Yang, Ming-Jim</creatorcontrib><creatorcontrib>Xie, Fagen</creatorcontrib><creatorcontrib>Turner, Stephen</creatorcontrib><creatorcontrib>Garfinkel, Alan</creatorcontrib><creatorcontrib>Weiss, James N</creatorcontrib><title>Short-term cardiac memory and mother rotor fibrillation</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description>University of California, Los Angeles (UCLA) Cardiovascular Research Laboratory, Departments of Medicine (Cardiology), Physiology, and Physiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California
Submitted 2 September 2005
; accepted in final form 18 June 2006
Short-term cardiac memory refers to the effects of pacing history on action potential duration (APD). Although the ionic mechanisms for short-term memory occurring over many heartbeats (also called APD accommodation) are poorly understood, they may have important effects on reentry and fibrillation. To explore this issue, we incorporated a generic memory current into the Phase I Luo and Rudy action potential model, which lacks short-term memory. The properties of this current were matched to simulate quantitatively human ventricular monophasic action potential accommodation. We show that, theoretically, short-term memory can resolve the paradox of how mother rotor fibrillation is initiated in heterogeneous tissue by physiological pacing. In simulated heterogeneous two-dimensional tissue and three-dimensional ventricles containing an inward rectifier K + current gradient, short-term memory could spontaneously convert multiple wavelet fibrillation to mother rotor fibrillation or to a mixture of both fibrillation types. This was due to progressive acceleration and stabilization of rotors as accumulation of memory shortened APD and flattened APD restitution slope nonuniformly throughout the tissue.
ventricular fibrillation; mathematical modeling; electrical restitution; action potential accommodation
Address for reprint requests and other correspondence: J. N. Weiss, David Geffen School of Medicine at UCLA, Division of Cardiology, 47-123 CHS, 10833 LeConte Ave., Los Angeles, CA 90095-1679 (e-mail: jweiss{at}mednet.ucla.edu )</description><subject>Action Potentials</subject><subject>Adaptation, Physiological</subject><subject>Animals</subject><subject>Cardiac arrhythmia</subject><subject>Cardiology</subject><subject>Cardiovascular system</subject><subject>Computer Simulation</subject><subject>Heart</subject><subject>Heart Conduction System - physiopathology</subject><subject>Models, Cardiovascular</subject><subject>Rabbits</subject><subject>Ventricular Fibrillation - physiopathology</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1qGzEYRUVIid20T1AoQxbZjau_0UjdBRM3hUAXTddC1o9HZsaaShoSv32U2I0h0NW3-M65XC4AXxBcINTgb2o7dlbFvIBQULrAEDZnYF4-uEYNEedgDgkjNUOkmYGPKW1hIVpGLsAMMS4QhWQO2t9diLnONg6VVtF4pavBDiHuK7Uz1RByZ2MVQw6xcn4dfd-r7MPuE_jgVJ_s5-O9BH9Wtw_Lu_r-14-fy5v7WlMMc204IbTVBlGjRaOpg1y4NXcYYqgU1RYTRUmjeQOJa4XlxtDWUcYN01AgQy7B9SF3jOHvZFOWg0_alhY7G6YkGacIY94W8OoduA1T3JVuEmPBeMM4LxA5QDqGlKJ1cox-UHEvEZQvo8p_o8rXUeXLqMX6eoye1oM1J-e4YgG-H4DOb7pHH60cu33yoQ-bvVxNff9gn_JbNBZYInmHOJSjcUVe_F9-q3OSyDMcbZnL</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Baher, Ali</creator><creator>Qu, Zhilin</creator><creator>Hayatdavoudi, Ashkan</creator><creator>Lamp, Scott T</creator><creator>Yang, Ming-Jim</creator><creator>Xie, Fagen</creator><creator>Turner, Stephen</creator><creator>Garfinkel, Alan</creator><creator>Weiss, James N</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Short-term cardiac memory and mother rotor fibrillation</title><author>Baher, Ali ; Qu, Zhilin ; Hayatdavoudi, Ashkan ; Lamp, Scott T ; Yang, Ming-Jim ; Xie, Fagen ; Turner, Stephen ; Garfinkel, Alan ; Weiss, James N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-d83347cd14dc95c4f089fb8f2020aa4ce23a435c8503f79e8dd47f468d6c091d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Action Potentials</topic><topic>Adaptation, Physiological</topic><topic>Animals</topic><topic>Cardiac arrhythmia</topic><topic>Cardiology</topic><topic>Cardiovascular system</topic><topic>Computer Simulation</topic><topic>Heart</topic><topic>Heart Conduction System - physiopathology</topic><topic>Models, Cardiovascular</topic><topic>Rabbits</topic><topic>Ventricular Fibrillation - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baher, Ali</creatorcontrib><creatorcontrib>Qu, Zhilin</creatorcontrib><creatorcontrib>Hayatdavoudi, Ashkan</creatorcontrib><creatorcontrib>Lamp, Scott T</creatorcontrib><creatorcontrib>Yang, Ming-Jim</creatorcontrib><creatorcontrib>Xie, Fagen</creatorcontrib><creatorcontrib>Turner, Stephen</creatorcontrib><creatorcontrib>Garfinkel, Alan</creatorcontrib><creatorcontrib>Weiss, James N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. 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Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>292</volume><issue>1</issue><spage>H180</spage><epage>H189</epage><pages>H180-H189</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><coden>AJPPDI</coden><abstract>University of California, Los Angeles (UCLA) Cardiovascular Research Laboratory, Departments of Medicine (Cardiology), Physiology, and Physiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California
Submitted 2 September 2005
; accepted in final form 18 June 2006
Short-term cardiac memory refers to the effects of pacing history on action potential duration (APD). Although the ionic mechanisms for short-term memory occurring over many heartbeats (also called APD accommodation) are poorly understood, they may have important effects on reentry and fibrillation. To explore this issue, we incorporated a generic memory current into the Phase I Luo and Rudy action potential model, which lacks short-term memory. The properties of this current were matched to simulate quantitatively human ventricular monophasic action potential accommodation. We show that, theoretically, short-term memory can resolve the paradox of how mother rotor fibrillation is initiated in heterogeneous tissue by physiological pacing. In simulated heterogeneous two-dimensional tissue and three-dimensional ventricles containing an inward rectifier K + current gradient, short-term memory could spontaneously convert multiple wavelet fibrillation to mother rotor fibrillation or to a mixture of both fibrillation types. This was due to progressive acceleration and stabilization of rotors as accumulation of memory shortened APD and flattened APD restitution slope nonuniformly throughout the tissue.
ventricular fibrillation; mathematical modeling; electrical restitution; action potential accommodation
Address for reprint requests and other correspondence: J. N. Weiss, David Geffen School of Medicine at UCLA, Division of Cardiology, 47-123 CHS, 10833 LeConte Ave., Los Angeles, CA 90095-1679 (e-mail: jweiss{at}mednet.ucla.edu )</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>16891403</pmid><doi>10.1152/ajpheart.00944.2005</doi></addata></record> |
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source | MEDLINE; American Physiological Society Paid; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
subjects | Action Potentials Adaptation, Physiological Animals Cardiac arrhythmia Cardiology Cardiovascular system Computer Simulation Heart Heart Conduction System - physiopathology Models, Cardiovascular Rabbits Ventricular Fibrillation - physiopathology |
title | Short-term cardiac memory and mother rotor fibrillation |
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