Alpha1-adrenergic stimulation of FGF-2 promoter in cardiac myocytes and in adult transgenic mouse hearts

Alpha1-adrenergic stimulation of FGF-2 promoter in cardiac myocytes and in adult transgenic mouse hearts

Fibroblast growth factor (FGF-2), a mitogenic, angiogenic, and cardioprotective agent, is reported to be released from the postnatal heart by a mechanism of transient remodeling of the sarcolemma during contraction. This release can be increased with adrenergic stimulation.

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Bibliographische Detailangaben
Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 1999-03, Vol.45 (3), p.H826
Hauptverfasser: Detillieux, Karen A, Meij, Johanna T A, Kardami, Elissavet, Cattini, Peter A
Format: Artikel
Sprache:eng
Schlagworte:
Enzymes
Genes
Heart
Proteins
Rodents
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Beschreibung
Zusammenfassung:Fibroblast growth factor (FGF-2), a mitogenic, angiogenic, and cardioprotective agent, is reported to be released from the postnatal heart by a mechanism of transient remodeling of the sarcolemma during contraction. This release can be increased with adrenergic stimulation.
ISSN:0363-6135
1522-1539