Melatonin improves cerebral circulation security margin in rats

Melatonin improves cerebral circulation security margin in rats

Because melatonin is a cerebral vasoconstrictor agent, we tested whether it could shift the lower limit of cerebral blood flow autoregulation to a lower pressure level, by improving the cerebrovascular dilatory reserve, and thus widen the security margin. Cerebral blood flow and cerebrovascular resi...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 1998-07, Vol.44 (1), p.H139-H144
Hauptverfasser: REGRIGNY, O, DELAGRANGE, P, SCALBERT, E, ATKINSON, J, LARTAUD-IDJOUADIENE, I
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Brain
Circulatory system
Fundamental and applied biological sciences. Psychology
Hemodynamics. Rheology
Rodents
Vertebrates: cardiovascular system
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Zusammenfassung:Because melatonin is a cerebral vasoconstrictor agent, we tested whether it could shift the lower limit of cerebral blood flow autoregulation to a lower pressure level, by improving the cerebrovascular dilatory reserve, and thus widen the security margin. Cerebral blood flow and cerebrovascular resistance were measured by hydrogen clearance in the frontal cortex of adult male Wistar rats.
ISSN:0363-6135
1522-1539