BDM drives protein dephosphorylation and inhibits adenine nucleotide exchange in cardiomyocytes

Contractile dysfunction plays a key role in injury sustained by ischemic myocardium at reperfusion, whereas interventions that impede hypercontracture enhance recovery. In permeabilized adult rat cardiomyocytes, the negative inotrope 2,3-butanedione monoxime (BDM; 10-50 mM) inhibited rigor at low Mg...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 1998-10, Vol.44 (4), p.H1260-H1266
Hauptverfasser:	STAPLETON, M. T, FUCHSBAUER, C. M, ALLSHIRE, A. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cardiology Drug therapy Fundamental and applied biological sciences. Psychology Heart Metabolism Pharmacology Proteins Vertebrates: cardiovascular system
Online-Zugang:	Volltext
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Zusammenfassung:	Contractile dysfunction plays a key role in injury sustained by ischemic myocardium at reperfusion, whereas interventions that impede hypercontracture enhance recovery. In permeabilized adult rat cardiomyocytes, the negative inotrope 2,3-butanedione monoxime (BDM; 10-50 mM) inhibited rigor at low MgATP concentration but stimulated net ATP hydrolysis.
ISSN:	0363-6135 1522-1539