Troponin I phosphorylation and myofilament calcium sensitivity during decompensated cardiac hypertrophy

We have measured myocyte cell shortening, troponin-I (Tn-I) phosphorylation, Ca2+ dependence of actomyosin adenosinetriphosphatase (ATPase) activity, adenosine 3',5'-cyclic monophosphate (cAMP) levels, and myofibrillar isoform expression in the spontaneously hypertensive rat (SHR) during d...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 1998-02, Vol.43 (2), p.H385-H396
Hauptverfasser:	MCCONNELL, B. K, SCHOMISCH MORAVEC, C, BOND, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy & physiology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Calcium Cardiology. Vascular system Cardiovascular disease Enzymes Experimental diseases Heart Medical sciences
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Beschreibung
Zusammenfassung:	We have measured myocyte cell shortening, troponin-I (Tn-I) phosphorylation, Ca2+ dependence of actomyosin adenosinetriphosphatase (ATPase) activity, adenosine 3',5'-cyclic monophosphate (cAMP) levels, and myofibrillar isoform expression in the spontaneously hypertensive rat (SHR) during decompensated cardiac hypertrophy (76 wk old) and in age-matched Wistar-Kyoto rat (WKY) controls.
ISSN:	0363-6135 1522-1539