Vanadate causes synthesis of endothelium-derived NO via pertussis toxin-sensitive G protein in pigs

Vanadate causes synthesis of endothelium-derived NO via pertussis toxin-sensitive G protein in pigs

The effects of sodium orthovanadate, an inhibitor of protein tyrosine phosphatases, on the endothelial nitric oxide (NO) pathway were studied in vitro. Results indicate that in porcine blood vessels, vanadate causes a synthesis of endothelium-derived NO for which endothelial tyrosine kinases and per...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 1996-07, Vol.40 (1), p.H296-H302
Hauptverfasser: NAKAIKE, R, SHIMOKAWA, H, KOJI OWADA, M, TOKUNAGA, O, YASUTAKE, H, KISHIMOTO, T, IMADA, C, SHIRAISHI, T, EGASHIRA, K, TAKESHITA, A
Format: Artikel
Sprache:eng
Schlagworte:
Antianginal agents. Coronary vasodilator agents
Biological and medical sciences
Blood vessels
Cardiovascular system
Gases
Hogs
Medical sciences
Pharmacology. Drug treatments
Proteins
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Zusammenfassung:The effects of sodium orthovanadate, an inhibitor of protein tyrosine phosphatases, on the endothelial nitric oxide (NO) pathway were studied in vitro. Results indicate that in porcine blood vessels, vanadate causes a synthesis of endothelium-derived NO for which endothelial tyrosine kinases and pertussis toxin-sensitive G protein are considered to be closely involved.
ISSN:0363-6135
1522-1539