TEA inhibits ACh-induced EDRF release: Endothelial Ca(2)(plus)-dependent K(plus) channels contribute to vascular tone

TEA inhibits ACh-induced EDRF release: Endothelial Ca(2)(plus)-dependent K(plus) channels contribute to vascular tone

A study examined the effects of potassium plus (K-plus)-channel blockers on acetylcholine (ACh)-induced relaxation of vascular smooth muscle, intracellular free calcium II plus concentration elevation and ACh-evoked K-plus current of endothelial cells of rabbit aorta. Calcium II plus-dependent K-plu...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 1994-09, Vol.36 (3), p.H1135
Hauptverfasser: Demirel, E, Rusko, J, Laskey, R E, Adams, D J, Van Breemen, C
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Calcium
Circulatory system
Potassium
Rabbits
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Zusammenfassung:A study examined the effects of potassium plus (K-plus)-channel blockers on acetylcholine (ACh)-induced relaxation of vascular smooth muscle, intracellular free calcium II plus concentration elevation and ACh-evoked K-plus current of endothelial cells of rabbit aorta. Calcium II plus-dependent K-plus channels are important for increasing calcium II plus during agonist stimulation.
ISSN:0363-6135
1522-1539