Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heart

Wang et al examined the role of the transforming growth factor (TGF)-beta1 signaling inhibitor Smad 7 in cardiac fibrosis. TGF-beta1 (10 ng/ml) was found to increase cytosolic Smad 7 expression in primary adult rat fibroblasts and induce rapid nuclear export of exogenous Smad 7 in COS-7 cells.

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Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2002-05, Vol.51 (5), p.H1685-H1696
Hauptverfasser:	BAIQIU WANG, JIANMING HAO, JONES, Stephen C, YEE, May-Sann, ROTH, Julie C, DIXON, Ian M. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cardiology. Vascular system Coronary heart disease Cytokines Heart Heart attacks Heart failure Medical sciences Rodents
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Wang et al examined the role of the transforming growth factor (TGF)-beta1 signaling inhibitor Smad 7 in cardiac fibrosis. TGF-beta1 (10 ng/ml) was found to increase cytosolic Smad 7 expression in primary adult rat fibroblasts and induce rapid nuclear export of exogenous Smad 7 in COS-7 cells.
ISSN:	0363-6135 1522-1539