Myocyte cytoskeletal disorganization and right heart failure in hypoxia-induced neonatal pulmonary hypertension

Previous studies have demonstrated that environmentally or genetically induced changes in the intracellular proteins that compose the cytoskeleton can contribute to heart failure. Because neonatal right ventricular myocytes are immature and are in the process of significant cytoskeletal change, we h...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2000-09, Vol.48 (3), p.H1365-H1376
Hauptverfasser:	LEMLER, Matthew S, BIES, Roger D, FRID, Maria G, SASTRAVAHA, Amornrate, ZISMAN, Lawrence S, BOHLMEYER, Teresa, GERDES, A. Martin, REEVES, John T, STENMARK, Kurt R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cardiology. Vascular system Heart Heart failure Heart failure, cardiogenic pulmonary edema, cardiac enlargement Hypertension Medical sciences Oxygen Pneumology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Previous studies have demonstrated that environmentally or genetically induced changes in the intracellular proteins that compose the cytoskeleton can contribute to heart failure. Because neonatal right ventricular myocytes are immature and are in the process of significant cytoskeletal change, we hypothesized that they may be particularly susceptible to pressure stress.
ISSN:	0363-6135 1522-1539