Evidence for a functional calcium-sensing receptor that modulates myogenic tone in rat subcutaneous small arteries

Evidence for a functional calcium-sensing receptor that modulates myogenic tone in rat subcutaneous small arteries

Myogenic tone of small arteries is dependent on the presence of extracellular calcium (), and, recently, a receptor that senses changes in Ca2+, the calcium-sensing receptor (CaR), has been detected in vascular tissue. We investigated whether the CaR is involved in the regulation of myogenic tone in...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 2005-04, Vol.57 (4), p.H1756-H1762
Hauptverfasser: OHANIAN, Jacqueline, GATFIELD, Kelly M, WARD, Donald T, OHANIAN, Vasken
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Blood vessels
Calcium
Fundamental and applied biological sciences. Psychology
Magnesium
Muscular system
Rodents
Vertebrates: cardiovascular system
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Zusammenfassung:Myogenic tone of small arteries is dependent on the presence of extracellular calcium (), and, recently, a receptor that senses changes in Ca2+, the calcium-sensing receptor (CaR), has been detected in vascular tissue. We investigated whether the CaR is involved in the regulation of myogenic tone in rat subcutaneous small arteries. Immunoblot analysis using a monoclonal antibody against the CaR demonstrated its presence in rat subcutaneous arteries. To determine whether the CaR was functionally active, segments of artery (
ISSN:0363-6135
1522-1539