Hybrid isoquinolines from Thalictrum foetidum : a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms
Thalfoetines A–D ( 1–4 ), unique hybrid aporphine alkaloids with a C-7 aromatic unit formed by a new C–C bond linking two building blocks, were isolated from Thalictrum foetidum . Their structures were elucidated by extensive spectroscopic and computational analysis. They inhibited bacteria signific...
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| Veröffentlicht in: | Organic Chemistry Frontiers 2019-10, Vol.6 (19), p.3428-3434 |
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| container_issue | 19 |
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| container_title | Organic Chemistry Frontiers |
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| creator | Ding, Cai-Feng Zhang, Rong-Ping Yu, Hao-Fei Yang, Jing Qin, Xu-Jie Dai, Zhi Liu, Ya-Ping Lu, Qiu-Min Lai, Ren Luo, Xiao-Dong |
| description | Thalfoetines A–D (
1–4
), unique hybrid aporphine alkaloids with a C-7 aromatic unit formed by a new C–C bond linking two building blocks, were isolated from
Thalictrum foetidum
. Their structures were elucidated by extensive spectroscopic and computational analysis. They inhibited bacteria significantly, and compound
1
damaged the cell structure of
Staphylococcus aureus
and inhibited its DNA synthesis. |
| doi_str_mv | 10.1039/C9QO00737G |
| format | Article |
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1–4
), unique hybrid aporphine alkaloids with a C-7 aromatic unit formed by a new C–C bond linking two building blocks, were isolated from
Thalictrum foetidum
. Their structures were elucidated by extensive spectroscopic and computational analysis. They inhibited bacteria significantly, and compound
1
damaged the cell structure of
Staphylococcus aureus
and inhibited its DNA synthesis.</description><identifier>ISSN: 2052-4129</identifier><identifier>ISSN: 2052-4110</identifier><identifier>EISSN: 2052-4129</identifier><identifier>EISSN: 2052-4110</identifier><identifier>DOI: 10.1039/C9QO00737G</identifier><language>eng</language><publisher>London: Royal Society of Chemistry</publisher><subject>Alkaloids ; Computer applications ; Cytology ; DNA biosynthesis ; Organic chemistry ; Staphylococcus aureus ; Structural damage ; Thalictrum</subject><ispartof>Organic Chemistry Frontiers, 2019-10, Vol.6 (19), p.3428-3434</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c259t-4da441ad2ec275cc449d852d99768dcdf0457e92b0e1690cc05987a1a92df20b3</citedby><cites>FETCH-LOGICAL-c259t-4da441ad2ec275cc449d852d99768dcdf0457e92b0e1690cc05987a1a92df20b3</cites><orcidid>0000-0002-6768-5679</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Ding, Cai-Feng</creatorcontrib><creatorcontrib>Zhang, Rong-Ping</creatorcontrib><creatorcontrib>Yu, Hao-Fei</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Qin, Xu-Jie</creatorcontrib><creatorcontrib>Dai, Zhi</creatorcontrib><creatorcontrib>Liu, Ya-Ping</creatorcontrib><creatorcontrib>Lu, Qiu-Min</creatorcontrib><creatorcontrib>Lai, Ren</creatorcontrib><creatorcontrib>Luo, Xiao-Dong</creatorcontrib><title>Hybrid isoquinolines from Thalictrum foetidum : a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms</title><title>Organic Chemistry Frontiers</title><description>Thalfoetines A–D (
1–4
), unique hybrid aporphine alkaloids with a C-7 aromatic unit formed by a new C–C bond linking two building blocks, were isolated from
Thalictrum foetidum
. Their structures were elucidated by extensive spectroscopic and computational analysis. They inhibited bacteria significantly, and compound
1
damaged the cell structure of
Staphylococcus aureus
and inhibited its DNA synthesis.</description><subject>Alkaloids</subject><subject>Computer applications</subject><subject>Cytology</subject><subject>DNA biosynthesis</subject><subject>Organic chemistry</subject><subject>Staphylococcus aureus</subject><subject>Structural damage</subject><subject>Thalictrum</subject><issn>2052-4129</issn><issn>2052-4110</issn><issn>2052-4129</issn><issn>2052-4110</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpNkMFLwzAYxYMoOOYu_gUBb0L1S9o0izcZugmDIc5zSZPUZrRNTVKkJ__1VSbo6b3D7_se7yF0TeCOQCruV-J1B8BTvj5DMwqMJhmh4vyfv0SLEA4AQCjLgfEZ-t6Mpbca2-A-B9u5xnYm4Mq7Fu9r2VgV_dDiyplo9WQesMSd-cJx7A12FZa983093WDb1ba00XYf-C3Kvh4bp5xSQ8By8GaScsTKteXEatwaVcvOhjZcoYtKNsEsfnWO3p-f9qtNst2tX1aP20RRJmKSaZllRGpqFOVMqSwTesmoFoLnS610BRnjRtASDMkFKAVMLLkkUlBdUSjTObo5_e39VNSEWBzc4LspsqBU5ITmXKQTdXuilHcheFMVvbet9GNBoPjZuPjbOD0CmJlwqw</recordid><startdate>20191007</startdate><enddate>20191007</enddate><creator>Ding, Cai-Feng</creator><creator>Zhang, Rong-Ping</creator><creator>Yu, Hao-Fei</creator><creator>Yang, Jing</creator><creator>Qin, Xu-Jie</creator><creator>Dai, Zhi</creator><creator>Liu, Ya-Ping</creator><creator>Lu, Qiu-Min</creator><creator>Lai, Ren</creator><creator>Luo, Xiao-Dong</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-6768-5679</orcidid></search><sort><creationdate>20191007</creationdate><title>Hybrid isoquinolines from Thalictrum foetidum : a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms</title><author>Ding, Cai-Feng ; Zhang, Rong-Ping ; Yu, Hao-Fei ; Yang, Jing ; Qin, Xu-Jie ; Dai, Zhi ; Liu, Ya-Ping ; Lu, Qiu-Min ; Lai, Ren ; Luo, Xiao-Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c259t-4da441ad2ec275cc449d852d99768dcdf0457e92b0e1690cc05987a1a92df20b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alkaloids</topic><topic>Computer applications</topic><topic>Cytology</topic><topic>DNA biosynthesis</topic><topic>Organic chemistry</topic><topic>Staphylococcus aureus</topic><topic>Structural damage</topic><topic>Thalictrum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, Cai-Feng</creatorcontrib><creatorcontrib>Zhang, Rong-Ping</creatorcontrib><creatorcontrib>Yu, Hao-Fei</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Qin, Xu-Jie</creatorcontrib><creatorcontrib>Dai, Zhi</creatorcontrib><creatorcontrib>Liu, Ya-Ping</creatorcontrib><creatorcontrib>Lu, Qiu-Min</creatorcontrib><creatorcontrib>Lai, Ren</creatorcontrib><creatorcontrib>Luo, Xiao-Dong</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Organic Chemistry Frontiers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, Cai-Feng</au><au>Zhang, Rong-Ping</au><au>Yu, Hao-Fei</au><au>Yang, Jing</au><au>Qin, Xu-Jie</au><au>Dai, Zhi</au><au>Liu, Ya-Ping</au><au>Lu, Qiu-Min</au><au>Lai, Ren</au><au>Luo, Xiao-Dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hybrid isoquinolines from Thalictrum foetidum : a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms</atitle><jtitle>Organic Chemistry Frontiers</jtitle><date>2019-10-07</date><risdate>2019</risdate><volume>6</volume><issue>19</issue><spage>3428</spage><epage>3434</epage><pages>3428-3434</pages><issn>2052-4129</issn><issn>2052-4110</issn><eissn>2052-4129</eissn><eissn>2052-4110</eissn><abstract>Thalfoetines A–D (
1–4
), unique hybrid aporphine alkaloids with a C-7 aromatic unit formed by a new C–C bond linking two building blocks, were isolated from
Thalictrum foetidum
. Their structures were elucidated by extensive spectroscopic and computational analysis. They inhibited bacteria significantly, and compound
1
damaged the cell structure of
Staphylococcus aureus
and inhibited its DNA synthesis.</abstract><cop>London</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/C9QO00737G</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6768-5679</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2052-4129 |
| ispartof | Organic Chemistry Frontiers, 2019-10, Vol.6 (19), p.3428-3434 |
| issn | 2052-4129 2052-4110 2052-4129 2052-4110 |
| language | eng |
| recordid | cdi_proquest_journals_2296126793 |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Alkaloids Computer applications Cytology DNA biosynthesis Organic chemistry Staphylococcus aureus Structural damage Thalictrum |
| title | Hybrid isoquinolines from Thalictrum foetidum : a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms |
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